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Blood Test Could Predict Parkinson’s 7 Years before Symptoms – AI Test
A simple blood test could predict Parkinson’s disease seven years before symptoms appear, marking a “major step forward” in diagnosis of the condition.
Researchers believe early prediction and diagnosis would help in finding treatments that could slow or stop Parkinson’s.
Parkinson’s disease is a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves.
The test uses artificial intelligence (AI) to predict the disease, which is caused by the death of nerve cells in the part of the brain that controls movement.
When these nerve cells die or become impaired, they lose the ability to create a chemical called dopamine.
People with Parkinson’s are currently treated with dopamine replacement therapy after they have already developed symptoms, such as tremors or slowness of movement.
It is thought that early diagnosis and treatment would help protect the dopamine-producing brain cells.
Dr Michael Bartl, co-first-author of University Medical Centre Goettingen and Paracelsus-Elena-Klinik Kassel, alongside Dr Jenny Hallqvist, UCL Queen Square Institute of Neurology, said: “By determining eight proteins in the blood, we can identify potential Parkinson’s patients several years in advance.
“This means that drug therapies could potentially be given at an earlier stage, which could possibly slow down disease progression or even prevent it from occurring.”
Professor David Dexter, director of research at Parkinson’s UK, said: “This research, co-funded by Parkinson’s UK, represents a major step forward in the search for a definitive and patient-friendly diagnostic test for Parkinson’s.
“Finding biological markers that can be identified and measured in the blood is much less invasive than a lumbar puncture, which is being used more and more in clinical research.”
The research found that when a branch of AI called machine learning analysed a panel of eight blood-based biomarkers whose concentrations are altered in patients with Parkinson’s, it could provide a diagnosis with 100% accuracy.
Professor Kevin Mills, senior author of UCL Great Ormond Street Institute of Child Health, said: “As new therapies become available to treat Parkinson’s, we need to diagnose patients before they have developed the symptoms.
“We cannot regrow our brain cells and therefore we need to protect those that we have.
“At present we are shutting the stable door after the horse has bolted and we need to start experimental treatments before patients develop symptoms.”
He added that with sufficient funding, it is hoped the test will be used by the NHS within two years.
The experts suggest that with further research this test could potentially distinguish between Parkinson’s and other conditions that have some early similarities.
The team also looked at whether the test could predict the likelihood of someone going on to develop Parkinson’s.
Blood from 72 patients with Rapid Eye Movement Behaviour Disorder (iRBD) was analysed as it is known that about 75% to 80% of these people will go on to develop a synucleinopathy – a type of brain disorder caused by the abnormal build-up of a protein called alpha-synuclein in brain cells – including Parkinson’s.
The patients were followed up over 10 years and researchers say the AI predictions have so far been correct, with the team correctly predicting 16 patients would go on to develop Parkinson’s and being able to do this up to seven years before the onset of any symptoms.
According to Parkinson’s UK, around one in 37 people alive today in the UK will be diagnosed with Parkinson’s in their lifetime, and there are 153,000 people already living with the condition.
The researchers are hoping to secure funding to create a simpler test where a drop of blood can be spotted on a card and posted to the lab to investigate if it can predict Parkinson’s even earlier than the seven years before the onset of symptoms in this study.
The research, which was funded by an EU Horizon 2020 grant, Parkinson’s UK, the National Institute for Health and Care Research GOSH Biomedical Research Centre, and the Szeben-Peto Foundation, is published in Nature Communications.
Mobility technology company, Moove has raised $250 million in a Series C funding round at a valuation of $2.1 billion, reaching unicorn status.
The startup will deploy the fresh capital to build out autonomous vehicle infrastructure, expand fleet ownership, construct robotics-focused “Nests” for charging and maintenance, and grow its autonomous workforce from 150 to 500 by year-end.
The company plans to enter additional global markets, reflecting a strategy to build the operational infrastructure required for large-scale autonomous transportation rather than simply supplying vehicles.
Led by Mubadala Investment Company and co-led by Woven Capital, Toyota’s Growth Fund, and Ion Pacific, the round also included new investors BlueCrest Capital Management, Sona Asset Management and The Raptor Group, alongside existing backers BlackRock, MUFG, Franklin Templeton and Uber.
“Autonomous mobility is becoming an infrastructure race requiring fleets, charging systems, maintenance, data infrastructure and continuous city-level operations,” said Ladi Delano, co-founder, co-CEO and advisory board chairman of Moove.
Founded in Lagos in 2020, Moove has grown into a global mobility platform employing about 3,300 people across 29 cities in 13 countries, operating approximately 42,000 vehicles and reaching $420 million in annualised recurring revenue.
It has expanded organically and through acquisitions, including Kovi in Brazil and Tokyo Taxi in Japan. Moove also operates autonomous vehicle fleets in partnership with Waymo in Phoenix and Miami, with London expected to join its footprint.
The $2.1 billion valuation places Moove among Africa’s small group of tech unicorns, alongside Flutterwave, OPay, Moniepoint, Andela, Chipper Cash, Wave, Tyme, MNT-Halan and Interswitch.
The $250 million round is the largest single funding deal announced by an African startup this year, though EV mobility firm Spiro raised $270 million cumulatively across two separate rounds.
The World Bank Group has announced the 31-month debarments of United Aviation Services Limited (UNASEL), a transportation services company based in Nigeria, and Air Vice Marshal Alkali Mamu, its owner and president, “in connection with fraudulent practices under the Enhancing Niger Northeastern Connectivity Project,” according to a press release issued by the multilateral development bank.
The statement said that the project aims to enhance connectivity and road safety along the Zinder-Agadez Road section and improve access to basic socioeconomic infrastructure for selected communities in that road section.
However, according to the statement: “UNASEL and Mr. Mamu presented false experience documents in a prequalification application to qualify for a contract under the project. This was a fraudulent practice under the World Bank’s sanctions framework.”
“The debarments make UNASEL and Mr. Mamu ineligible to participate in projects and operations financed by Bank Group institutions. The debarments are part of two settlement agreements under which UNASEL and Mr. Mamu admit culpability for the underlying sanctionable practices,” it added.
The statement further said: “Per the Bank Group Sanctioning Guidelines, the settlement agreements provide for a reduced period of debarment in light of UNASEL and Mr. Mamu’s cooperation.
As a condition for release from sanction under the terms of the settlement agreements, UNASEL and Mr. Mamu commit to developing and implementing integrity compliance measures that reflect the relevant principles set out in the Bank Group Integrity Compliance Guidelines, and Mr. Mamu further agrees to complete corporate ethics training.
UNASEL and Mr. Mamu also commit to continue to fully cooperate with the Bank Group’s Integrity Vice Presidency.
“The debarments of UNA SEL and Mr. Mamu qualify for cross-debarment by other multilateral development banks under the Agreement for Mutual Enforcement of Debarment Decisions that was signed on April 9, 2010.”
Governor Peter Mbah of Enugu State, has approved the allocation of a parcel of land in Enugu, the state capital, for the establishment of a state-of-the-art Digital Fabrication Centre by the Industrial Training Fund.
Mbah announced this while receiving a delegation from the Industrial Training Fund on a courtesy visit to the Government House, Enugu.
The ITF disclosed this on Friday in a statement signed by its Director of Press and Public Relations, Thomas Ngor.
According to the statement, Mbah described the proposed project as timely and aligned with his administration’s vision of transforming Enugu into a leading destination for investment, innovation and technology-driven industrial development.
He noted that the future of economic prosperity lies in deliberate investments in human capital and emerging technologies, adding that the state has continued to create an enabling environment for innovation, enterprise and sustainable growth.
The governor explained that his administration has made technical education compulsory in the state’s basic education system, with emphasis on digital literacy, robotics and mechatronics to prepare learners for the future of work.
According to him, many traditional trades are now driven by digital technologies, making it imperative to equip young people with relevant technical competencies that will enable them to compete globally and contribute meaningfully to economic development.
Governor Mbah further disclosed that his administration has built smart schools across the state, equipped with robotics centres, mechatronics laboratories and other modern learning facilities, to prepare youths for the evolving global economy.
He noted that artificial intelligence is expected to contribute about $20tn to the global economy in the coming years.
He therefore stressed that the state must be intentional about upskilling its citizens, adding that the establishment of the ITF Digital Fabrication Centre will significantly strengthen the state’s drive to build a knowledge-based economy, foster innovation, promote local manufacturing and create employment opportunities for its growing youthful population.
Earlier, Afiz Ogun, the Director-General of the ITF, who led the delegation, said that upon his appointment by President Bola Tinubu, he was mandated to upskill Nigerian artisans to international standards.
He explained that the Fund subsequently repositioned its technical and vocational skills development efforts through strategic initiatives, including the Skill-Up Artisans Programme, which is designed to train, certify and license Nigerian artisans to international standards.
Ogun disclosed that the Fund had already established a Digital Fabrication Centre in Ikeja, Lagos, with the capacity to produce more than 400 different products. He therefore requested the allocation of land in Enugu State to establish a similar centre with the same production capacity.
According to him, the initiative is aimed at promoting industrialisation, reducing dependence on imports and preparing Nigerians for opportunities in the Fourth Industrial Revolution.
He also reaffirmed the Fund’s readiness to enter into public-private partnerships that will transform Nigeria’s artisanal ecosystem.
Ogun further noted that digital technologies, including artificial intelligence, robotics and computer-aided manufacturing, are rapidly transforming the global economy, making it imperative for Nigeria to deliberately invest in upskilling its workforce to remain globally competitive.
The ITF delegation was later conducted on a guided tour of facilities at one of the smart schools established by the Enugu State Government.
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