News
Breakthrough as New Vaccine Clears HIV Virus in Monkeys
Global science has finally confirmed cure for Human Immune Virus (HIV), one of the world killer diseases as new studies have proved a vaccine for the monkey equivalent of HIV can eradicate the virus.
The latest report further explained that the new vaccine which cures simian immunodeficiency virus (SIV), an infection found in monkeys similar to HIV, would ultimately help scientists create a human version for HIV.
In recent years, spates of findings have shown that HIV can essentially be eradicated in some patients.
Since then, scientists have been scrambling to ultimately find a cure that could drastically change the lives of millions of people worldwide.
Since the beginning of the epidemic, almost 70 million people have been infected with the HIV virus and about 35 million people have died of AIDS.
Globally, 34.0 million people were living with HIV at the end of 2011. Sub-Saharan Africa remains most severely affected, with nearly one in every 20 adults (4.9 per cent) living with HIV and accounting for 69 per cent of the people living with HIV worldwide.
In Nigeria, it is estimated that 3.4 million persons live with the virus.
According to the study from the Vaccine and Gene Therapy Institute at Oregon Health and Science University, published in the journal Nature, researchers tested the vaccine on 16 monkeys infected with an aggressive form of SIV called SIVmac239.
Nine of the 16 monkeys had the infection completely eliminated from their bodies.
These monkeys were still infection-free between one-and-a-half to three years later. Further research is needed to determine why the vaccine only worked on some monkeys. Researchers also hope to test how the vaccine affects monkeys already infected with SIV, and eventually, if the vaccine could work in humans.
A potential HIV vaccine is still years away. But recent research has developed two vaccines for other infectious diseases that could be available sooner.
Acquired Immune Deficiency Syndrome (AIDS) was first recognized as a new disease in 1981 when increasing numbers of young homosexual men succumbed to unusual opportunistic infections and rare malignancies.
A retrovirus, now termed human immunodeficiency virus type 1 (HIV-1), was subsequently identified as the causative agent of what has since become one of the most devastating infectious diseases to have emerged in recent history.
HIV-1 spreads by sexual, percutaneous, and perinatal routes, however, 80 per cent of adults acquire HIV-1 following exposure at mucosal surfaces, and AIDS is thus primarily a sexually transmitted disease.
But based on the latest discovery, the authors said that they will adopt similar approach adopted for the monkeys to test a vaccine for HIV in humans. Commenting, Prof Louis Picker, from the Vaccine and Gene Therapy Institute at Oregon Health and Science University, said: “It is always tough to claim eradication – there could always be a cell which we didn’t analyse that has the virus in it.
But for the most part, with very stringent criteria… there was no virus left in the body of these monkeys.”
The research team looked at an aggressive form of virus called SIVmac239, which is up to 100 times more deadly than HIV. Infected monkeys usually die within two years, but in some inoculated primates, the virus did not take hold.
The vaccine is based on another virus called cytomegalovirus (CMV), which belongs to the herpes family.
It used the infectious power of CMV to sweep throughout the body. But instead of causing disease, it has been modified to spur the immune system into action to fight off the SIV molecules.
“It maintains an armed force, that patrols all the tissues of the body, all the time, indefinitely,” explained Prof Picker. The researchers gave rhesus macaque monkeys the vaccine, and then exposed them to SIV.
They found that at first, the infection began to establish and spread. But then the monkeys’ bodies started to respond, searching out and destroying all signs of the virus.
Of the monkeys that successfully responded to the vaccine, they were still clear of infection between one-and-a-half and three years later.
Prof Picker said his team was still trying to work out why the vaccination worked in only about half of the monkeys. “It could be the fact that SIV is so pathogenic that this is the best you are ever going to get.
There is a battle going on, and half the time the vaccine wins and half the time it does not,” he said. The researchers are now testing the vaccine to see if it can be used after SIV exposure to treat and potentially cure infected monkeys. They also want to see if the technique could work in humans.
Prof Picker said: “In order to make a human version, we have to make sure it is absolutely safe. We have now engineered a CMV virus which generates the same immune response, but has been attenuated (modified to lose its virulence) to the point where we think it is unequivocally safe.”
This would first have to pass through the regulatory authorities, but if it does, he said he hoped to start the first clinical trials in humans in the next two years.
Commenting on the research, Dr Andrew Freedman, from Cardiff University School of Medicine, said: “This suggests that prophylactic vaccines – vaccines designed to prevent infection – using CMV vectors may be a promising approach for HIV. While they may not prevent the initial infection, they might lead to subsequent clearance, rather than the establishment of chronic infection.”
The UK has pledged £1 billion to Nigeria’s fight against malaria and other diseases from 2024 to 2026.
Ebere Anyachukwu, health adviser at the British High Commission, announced this on World Malaria Day in an interview with NAN.
This contribution supplements existing funds from other donors and will primarily support the procurement of insecticides, treated bed nets, malaria diagnostics, and chemoprevention efforts.
“There are some states in Nigeria where malaria is seasonal. Those are states where chemoprevention is used to prevent children from coming down with malaria,“ he said.
“In those states, malaria spreads in a few months within a year, and during that period, there is a high level of malaria transmission in children, resulting in lots of deaths.”
The health adviser said children in such states are usually given malaria drugs, whether or not they have the infection.
He said the UK is a big contributor to the global fund, currently supporting about 13 states in Nigeria.
He listed the states to include Adamawa, Delta, Gombe, Jigawa, Kaduna, Kano, Katsina, Kwara, Niger, Ogun, Osun, Yobe and Taraba.
“With the global funding support, there has been a significant reduction of malaria-related deaths in children in Nigeria,“ Anyachukwu said.
The story has often been told in tech circles of how a relatively unknown Nigerian female student became a sensation of sorts among the international student population back in the early 80s in India owing to the unusual course of study she was undertaking.
Chioma Ekeh
Electing to study Mathematics at Bachelor’s degree level – a course that required not only battling differential equations, calculus, advanced algebra, and so on, but also pitting one’s wits against that of wizened professors – is not a task for the faint-hearted. But that was the path that this unusual lady took at Punjab University, located in the culturally rich and aesthetically pleasing city of Chandigarh, India.
It was a decision that would lead Chioma Ekeh (nee Emelonye) along the path of meeting the love of her life, a certain Leo Stan Ekeh and returning to Nigeria with him to play a leading role in shaping the course of technology distribution in Africa.
Undoubtedly, unusual may also be a word that defines Chioma and Leo Stan Ekeh’s remarkable journey together. A power couple and exemplary partners who have worked together for over 30 years building a successful technology empire is a rarity, one that is not often seen.
That sojourn to India and her subsequent career trajectory laid the groundwork for the impressive reputation Chioma Ekeh has built in the highly competitive technology space. Business associates and representatives of global brands never fail to cite her intellect and brainpower.
Job seekers who cross her path during interviews often recall being asked to solve a simple arithmetic problem. For those who eventually become employees, there is never-ending adulation.
Her husband, Leo Stan Ekeh, describes her as the integral analytics, the backbone behind the brilliant success of the Zinox Group where she has continued to support all the businesses across the board.
Such is the cerebral aptitude of this unusual woman that she is reported to have taken the stage once at a company-wide business review to present a financial report punctuated by humongous accurate numbers, figures and percentages, all from memory and without recourse to any notes, a device or an actual presentation document.
Born on April 25, 1964, the story of the impressive diffusion, accessibility, useability and affordability of cutting-edge technology devices and solutions in Nigeria and indeed, sub-Saharan Africa will be grossly incomplete without a detailed citation on Chioma Ekeh and the leadership role she has played – one she has continued to play as a silent innovator and disruptor–alongside her legendary spouse.
A Fellow of the Chartered Institute of Certified Accountants (FCCA, UK), Mrs. Chioma Ekeh is the brains behind TD Africa, a regional technology distribution powerhouse headquartered in Nigeria and with branches across Africa and in four other continents.
A company she led from start-up stage, TD Africa with Chioma Ekeh as CEO, pioneered ICT distribution in Sub-Saharan Africa and has remained the industry leader by market share in the region and the biggest provider of credit to resellers.
Founded in 1999, TD Africa is Africa’s leading distributor of technology and lifestyle products, boasting an unmatched and growing network of partnership with global brands like HP, Microsoft, Apple, Starlink, IBM, Dell Technologies, Ring (by Amazon), Cisco, Lenovo, APC by Schneider Electric, Samsung, Bosch, Phillips, Logitech, Vivo, among several others. Under Chioma’s exemplary leadership, the company has achieved numerous milestones, earned a long list of local and international awards/accolades and ensured Nigeria and indeed Africa is reckoned with at the global table of technology conversations and discussion-making.
However, this remarkable story may have turned out differently, had Chioma not returned to Nigeria under the guidance of her husband.
Armed with a formidable Mathematics degree after completing her studies in India, Chioma had the world at her feet and was the toast of leading companies the world over.
Moving to the United Kingdom at the invitation of her husband, Chioma joined the exalted league of Chartered Accountants and thereafter, bagged an MBA at the reputable Heriot Watts University.In 1987, she joined Sterling Deveraux as an Investment Analyst, engaging in researchand analyzing assets, such as stocks, bonds, currenciesand commodities.
Her acumen and exceptional skills were growing in demand and before long, she left Sterling Deveraux, joining the London Borough of Lewisham as an accountant in 1988.
Between 1988 and 1991, Chioma’s sterling work saw her rise swiftly through the ranks at the London Borough of Lewisham, moving from Accountant to Senior Auditor and then to Financial Auditor.
Certainly, Chioma Ekeh had a clear path to becoming CFO and possibly CEO at the London Borough of Lewisham or even going on immediately to taking up other elevated roles at other organizations. But the love of motherland and the call of her husband – Leo Stan Ekeh – to return home to Nigeria with him and build a technology legacy for Nigeria and Africa proved too strong.
Back home, Chioma Ekeh’s initial area of responsibility was with Task Systems Ltd., the first of many companies in the Zinox Group set up by Leo Stan Ekeh.
She took up the position of Financial Controller and spent six achievement-filled years at Task before driving the vision of technology distribution birthed by her husband in launching TD Africa where she became the company’s pioneer CEO.
A quiet, unassuming tech icon, Chioma Ekeh has acquired a well-deserved status as unarguably one of Nigeria’s top three leading Women-in-Tech, a female technology business leader with extensive years of proven capacity in building high-performing teams and transforming businesses beyond stakeholders’ expectations.
In partnership with her husband, Chioma Ekeh has played immense roles in growing and nurturing partner businesses, launching several thriving new businesses and successfully closing some of the biggest acquisitions in the technology space in Nigeria.
The Tech Experience Centre – Africa’s first technology experience centre – located at Yudala Heights, a sprawling edifice in the heart of Victoria Island – is another project that has Chioma Ekeh’s indelible signature on it.
The launch of the Tech Experience Centre in October 2020 received high praise from the Nigerian government and representatives of global Original Equipment Manufacturers (OEMs).
Under her guidance, Celebrating You, an annual showpiece celebratory event hosted by TD Africa has become unarguably the biggest year-end event in the Nigerian technology industry for over a decade.
Also, she has spearheaded several CSR projects, including The Herwakening – an empowerment programme for female entrepreneurs– and Girls in ICT – a project targeted at encouraging young girls to take up STEM (Science, Technology, Engineering, Mathematics) disciplines and considering careers in technology.
As she turns 60, Chioma Ekeh deserves rarefied mention and unmitigated encomiums. An amazon, this unusual female tech icon who has shattered several glass ceilings, knows no fatigue and has continued to innovate, effortlessly leading from the front.
National Association of Academic Technologists (NAAT), has proposed N350,000 as the new minimum wage for Technologists in the tertiary institutions.
Comrade Ibeji Nwokoma, national pesident of NAAT, stated this at 5th National Delegate Conference in University of Abuja.
Nwokoma, said the proposal was based on the present economic situation in the country occasioned by the removal of fuel subsidy, high inflationary rate and the attendant hardship.
Nwokoma maintained that technology rule the world and advanced development and shaping the landscape of education in developed countries.
Prof. Tahir Mamman, minister of Education, said the federal government will soon introduce the policy that will make skill acquisition compulsory for primary and secondary schools.
The minister said global space is driven by technology which the advanced world is using to solve problems and gaining grounds.
The Union protect, defend, and promote the rights and well being and interests of all members and to advance the cause of members, employed in Nigerian Tertiary Institutions Universities, Polytechnics, and Colleges of Education.
The theme of the conference is, “Technology, a recipe for national development and socioeconomic growth in the 21st century: the Nigeria quest for a better tomorrow.”
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