News
Scientists Find Combo Drugs that Kill Lung Cancer

There is hope for lung cancer sufferers worldwide as a breakthrough research has found that the use of two existing drugs could successfully treat the disease.
The study delves deep into the molecular survival kit of lung tumours.
Many cancer deaths are driven by the KRAS oncogene. KRAS is an essential gene, but in its mutant form, it is an important step in the generation of many types of cancer.
For over 30 years, the KRAS oncogene has been a focus of research. Finding a way to remove its teeth would be pivotal in the treatment of a range of cancers.
As part of this effort, rather than targeting the gene directly, some scientists have focused on pathways that are related to the errant gene.
One pathway of interest centres on insulin and insulin-like growth factor-1 (IGF-1). This pathway helps to regulate the uptake of nutrients into the cell, providing it with the energy and raw ingredients it needs to grow.
If the tumour cell’s fuel supply could be severed, its onward march might be halted. However, it is not clear whether KRAS oncogenes are reliant on this particular pathway, and, in clinical trials, results have not been encouraging.
In fact, one study in mice found that lung tumours actually became more aggressive after the pathway was suppressed.
Attacking KRAS-related pathways
Undeterred, a team from the Boston Children’s Hospital in Massachusetts used a fresh approach. In the mouse study mentioned above, the insulin/IGF-1 signalling pathway was only partially closed off. In the latest study, though, a genetic technique was used that shut it down entirely.
To do this, the scientists crossed two strains of genetically modified mice. The first is a well-used model for KRAS-driven lung cancer, and the other is a mouse used to study diabetes that lacks insulin/IGF-1 signalling.
In the diabetes mouse model, the insulin/IGF-1 pathway is unshackled by the deletion of two genes: Irs1 and Irs2. These encode “adaptor” proteins, which are essential for the smooth running of the insulin/IGF-1 pathway.
“Our study uses a robust way to block insulin/IGF-1 signalling and addresses a long-standing question in KRAS-mutant lung cancer. When you use genetics, results can be more conclusive,” said senior study author Nada Kalaany, Ph.D, an assistant professor at Harvard Medical School, Boston, MA
Using their new model, the scientists demonstrated that by suppressing the two adaptor proteins, insulin/IGF-1 signalling is blocked and lung tumours are significantly suppressed:
“Almost all animals in this lung cancer model typically die within 15 weeks of KRAS activation,” says Kalaany. “But, the ones that lost both Irs1 and Irs2 were completely fine — we saw almost no tumours at 10 to 15 weeks.”
This finding is important because drugs that block insulin/IGF-1 signalling are already in use and freely available.
The results are published this week in the Proceedings of the National Academy of Sciences. While the preliminary findings are hopeful, the researchers knew that there was more work to be done; cancer is a complex, ever-morphing disease with a terrifying knack for circumventing medical interventions.
Outfoxing lung cancer
To observe whether the cancer cells were able to navigate around this new roadblock, the team let the animals live longer to see what happened next.
As Kalaany explains, “Sure enough, at around 16 weeks, we started seeing some tumours. So, then we asked, how were these tumour cells able to overcome loss of Irs1 and Irs2?”
The answer was found in the levels of essential cellular building blocks: amino acids. Tumour cells lacking the adaptor proteins failed to move amino acids into their cells, despite a plentiful supply outside of the cell.
“Growth factors, like IGF-1, tell cells that nutrients are around,” says Kalaany, “so when you suppress their signalling, the tumour cells don’t take up the amino acids and think they are starved.”
“But we found that the tumour cells can compensate for this and break down their own proteins to generate amino acids.”
So, the KRAS-driven tumours threw out a curve ball: they had, once again, figured out a workaround. By breaking themselves down — in a process known as autophagy — they can generate the raw material they need to thrive.
The researchers, however, were one step ahead.
Heading cancer off at the pass
Drugs that inhibit protein breakdown are already available. These include chloroquine, which is currently involved in a number of cancer drug trials, and bortezomib, which blocks proteasomes (protein-digesting structures) and is already used to treat myeloma.
When the two prongs of the attack were combined, the results were more than encouraging. They found that tumour cells lacking Irs1 and Irs2 did not grow well, and, when the inhibitors were added, growth stopped almost completely.
Additional studies will now be needed to understand how these two drug types might interact in a patient. However, this is a considerable breakthrough, and the researchers are excited to take it to the next phase.
“Our work tries to identify metabolic dependencies and vulnerabilities in tumours,” says Kalaany. “If we identify collaborators, we would love to have a clinical trial in non-small-cell lung cancer combining IGF-1 inhibitors with autophagy inhibitors or proteasome inhibitors.”
By testing to breaking point every part of a tumour cell’s survival kit, researchers will, one day, beat cancer.
News
Pay Your taxes for Me to Do More – Tinubu

President Bola Tinubu on Thursday urged Nigerians to pay their taxes, because the revenue is critical for his administration’s Renewed Hope Agenda to fund public infrastructure like roads, hospitals, and amenities across the country.

President Bola Tinubu
He spoke during the commissioning of interchange at Arterial Road N16 – Ring Road III Intersection linking Jahi District to Gwarimpa District of the FCT.
The project was among those earmarked to celebrate his third year anniversary and he was represented at the commissioning by Godswill Akpabio, Senate President.
He said: “I’m very proud to stand here to commission this Arterial road interchange N16 linking Jahi district to Gwarimpa District of the FCT.
“This is not just a bridge and slip roads, this is freedom of movement and time returned to the people, this is renewed hope that you can even drive on. This intersection used to choke the entirety of Abuja, gridlock stretched from Maitama to Gishiri, from Jahi to Gwarimpa; hours lost, fuel wasted, business were lost but today that story ends.
“This interchange opens up critical districts of the FCT and connects them smoothly to the rest of the FCT. Workers will get home earlier, security will improve because criminals strive when security stands still.
“Ladies and gentlemen, infrastructure is the foundation of prosperity which is the cardinal principle of this administration. Roads are the arteries of a nation, when we connect districts we connect destines and that is the logic of the renewed hope agenda, build the roads unlock the economy and let Nigerians strive.
“The Jahi-Gwarimpa interchange is prove that Nigeria is not beyond redemption. With focus, discipline, and political will, Nigeria will deliver and we are delivering, the FCT is delivering.”
The president also charged Nigerians and residents of the FCT to pay their taxes.
According to Tinubu, it would allow his administration to provide more infrastructural projects.
“Also pay your taxes and levies so that government can do even more for you,” he added.
News
MTN ASAP Enugu Stakeholders’ Conference Rallies More Action Against Youth Drug Abuse, Unveils N33Bn ASAP Impact

In a renewed push to confront the rising tide of drug abuse among Nigerian youth, stakeholders converged on Tuesday, June 9, 2026, at the ICC Dome, Enugu, for a State Stakeholders’ Engagement convened under the Anti-Substance Abuse Programme (ASAP).

The conference brought together government representatives, educators, development partners, and civil society actors to chart a unified path against substance abuse, with disclosures at the gathering revealing that an estimated ₦33 billion has so far been committed to developmental projects, programmes, and initiatives across the country, interventions that have impacted more than 33 million Nigerians directly and reached over 100 million through advocacy and awareness campaigns.
The Executive Governor of Enugu State, Barr. Peter Mbah, represented by the Secretary to the State Government, Prof. Chidiebere Onyia, commended the Foundation for its sustained investment in youth development and the fight against substance abuse.
He noted that the state’s transformation agenda is anchored in youth empowerment, education, healthcare, and human capital development – areas where the Foundation’s ₦33 billion commitment was already making a measurable difference.
“The MTN Foundation’s investment in youth development and the fight against substance abuse aligns directly with our administration’s transformational agenda. Initiatives like ASAP are exactly the kind of partnerships that move the needle on national development,” Prof. Onyia said.
He further urged other private sector players to emulate the Foundation’s example, stressing that the scale of Nigeria’s drug abuse demands sustained collaboration between government, the private sector, development partners, and civil society.
Addressing stakeholders, Odunayo Sanya, Executive Director of the MTN Foundation, said the Foundation, established in 2004 and fully funded by MTN Nigeria, was created to drive impact across health, capacity building, and economic empowerment, with deliberate focus on young people, who constitute the majority of Nigeria’s population.
She explained that the ASAP initiative, launched in 2019 in partnership with the National Drug Law Enforcement Agency (NDLEA) and the United Nations Office on Drugs and Crime (UNODC), was designed to reduce first-time drug use among young Nigerians through awareness campaigns and school-based interventions.
“We have reached over 50,000 students across the country and trained about 1,556 teachers as part of our efforts to create anti-drug ambassadors in schools and communities.”
“For us at the MTN Foundation, saving even one young person from substance abuse is a worthwhile achievement. The consequences go beyond the individual and affect families, communities, and the nation at large,” Odunayo said.
Looking ahead, she disclosed that the Foundation plans to reach more than 20,000 additional students in 2026 through expanded stakeholder engagements, school-based interventions, teacher training programmes, and community awareness campaigns.
She described substance abuse as a major threat to families, communities, and national development, stressing the urgent need for collective action to shield young people from addiction.
According to her, the Foundation’s mission is rooted not just in numbers, but in human outcomes – the lives, families, and futures it helps preserve.
The Executive Director, on her part, called on parents, educators, faith leaders, and community influencers to remain active partners in safeguarding the next generation from the dangers of substance abuse.
The intervention comes at a critical time. Fresh data presented at the conference indicate that over 360,000 youths in Enugu State – approximately 13.4% of the state’s young population – are actively involved in drug use.
Currently, the MTN Foundation (MTNF) and the United Nations Office on Drugs and Crime (UNODC) are conducting a comprehensive National Substance Use Survey to gather grassroots data on drug abuse, especially among secondary school students.
News
ICFJ, Wikimedia Honour Nigerian, African Journalists for Outstanding Reporting

International Center for Journalists (ICFJ), in partnership with the Wikimedia Foundation, has named three African journalists as recipients of the 2026 Open the Knowledge Journalism Awards, with two Nigerians emerging as first and second-place winners.

The awards recognise journalists whose well-researched reporting helps expand knowledge about Africa and serves as reliable source material for volunteer editors who develop content on Wikipedia.
Wikipedia, the online encyclopedia operated by the Wikimedia Foundation, relies on evidence-based reporting to improve and expand its content, making journalists key contributors to building a more comprehensive global knowledge base.
Earlier this year, African journalists living on the continent were invited to nominate articles they had written that contribute to expanding knowledge about Africa, particularly in the areas of women and youth, as well as arts, culture, heritage and sports.
The organisers said a total of 320 entries were received from journalists across 40 African countries.
The first prize was awarded to Nigerian freelance journalist, Rakiya Muhammad, for her article, West Africa’s Borderless Women: Inside the Yoruba Sisterhood Linking Nigeria and Côte d’Ivoire, published in RM Times.
The story documents the decades-long migration of women from Ejigbo in Osun State to Côte d’Ivoire in search of economic opportunities.
According to the report, the women have become a dominant force in markets in Abidjan while strengthening cultural and economic ties between Nigeria and Côte d’Ivoire.
The article also revealed that as much as 80 per cent of Ejigbo’s economy is supported by remittances and investments from its people living in Côte d’Ivoire.
Reacting to the recognition, Muhammad said the award had renewed her commitment to telling authentic stories that place African women at the centre of development, leadership and social change.
“Receiving this honour renews my passion for telling stories that place African women at the heart of the narrative as active agents of development, leadership and social change.
“The recognition rekindles my commitment to documenting positive stories about Africa with authenticity and depth, while shedding light on the gendered dimensions often overlooked in broader discussions,” she said.
Second place went to another Nigerian journalist, Abiodun Adewale of The Punch, for his story, Breaking Boundaries: How Nigeria’s U-19 Women Are Rewriting Cricket History.
The article chronicles the preparation and performance of Nigeria’s Junior Female Yellow Greens at the 2025 International Youth Cricket World Cup.
The organisers noted that the story highlighted the growing popularity of cricket in Nigeria, a sport that receives relatively limited media attention compared to other sporting disciplines.
A special recognition award was presented to Kenyan journalist Angeline Ochieng of Nation Media Group for her article, The Converts: How Reformed Midwives Are Ending Maternal Deaths, published in the Daily Nation.
The story focuses on former traditional birth attendants in rural Kenya who abandoned the practice to advocate hospital deliveries, contributing to a reduction in maternal deaths and childbirth complications.
President of ICFJ, Sharon Moshavi, said journalism and Wikipedia have a mutually beneficial relationship.
According to her, Wikipedia’s volunteer editors rely on independent journalism to build a more complete knowledge resource, while journalists benefit from the encyclopedia’s global and multilingual reach.
“These awards recognise that relationship and the African journalists who are making our digital information ecosystems stronger,” she said.
Chief Communications Officer of the Wikimedia Foundation, Anusha Alikhan, said although Wikipedia is the largest encyclopedia ever created, it remains incomplete.
She said stories written by Africans about issues affecting the continent were essential to ensuring that the encyclopedia reflected diverse experiences and perspectives.
“We celebrate the three journalists who have received the Open the Knowledge Journalism Awards and thank them for making this kind of reporting possible,” she said.
President of Wikimedia Nigeria and member of this year’s awards selection committee, Olaniyan Ishola Oulushola, commended the quality of the winning entries.
He said each of the selected articles presented opportunities to improve information about Africa on Wikipedia.
“From documenting the history of women cross-border traders in West Africa to the achievements of female cricketers, each of these articles brings us a step closer to closing the knowledge gaps we are working on every day,” he said.
The organisers noted that Wikipedia marked its 25th anniversary in January 2026.
They said the platform is currently among the world’s 10 most-visited websites and remains the only one in that category operated by a non-profit organisation.
According to them, Wikipedia currently hosts more than 65 million articles in over 300 languages, created by nearly 250,000 volunteer editors worldwide, attracting close to 15 billion page views every month.
However, they observed that many topics relating to Africa remain underrepresented, with only about 3.7 per cent of articles on the English version of Wikipedia focusing on the continent.
They explained that the knowledge gap reflects broader shortcomings in global media coverage, noting that new information can only be added to Wikipedia when supported by citations from published and reliable sources.
The 2026 award recipients were selected by a committee comprising African civil society leaders, academics, representatives of ICFJ and the Wikimedia Foundation, as well as members of the Wikipedia volunteer community.
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